Main Results - Brain structures
Effect size graph - Comorbidity in full sample

P-value graph - Depression - full sample
## Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
## ℹ Please use `linewidth` instead.

P-value graph - Depression - sex-stratified sample

P-value graph - Chronic Pain Status - full sample

P-value graph - Chronic Pain - sex-stratified sample

Cortex map: chronic pain

Subcortex volume map: chronic pain

## merging atlas and data by 'region'
## merging atlas and data by 'region'
## merging atlas and data by 'region'
## merging atlas and data by 'region'

Cortex map: depression

Subcortex volume map: depression

## merging atlas and data by 'region'
## merging atlas and data by 'region'
## merging atlas and data by 'region'
## merging atlas and data by 'region'



DTI: MD map

DTI: FA map

Number of significant hits
sum(res_comorbidity_brain_structure_all_save$p.adjust < 0.05)
## [1] 94
sum(res_comorbidity_brain_structure_female_save$p.adjust < 0.05)
## [1] 88
sum(res_comorbidity_brain_structure_male_save$p.adjust < 0.05)
## [1] 4
sum(brain_structure_CP_all$`Adjusted p-value < 0.05` == "Yes")
## [1] 50
sum(brain_structure_CP_female$`Adjusted p-value < 0.05` == "Yes")
## [1] 38
sum(brain_structure_CP_male$`Adjusted p-value < 0.05` == "Yes")
## [1] 14
sum(brain_structure_MDD_all$`Adjusted p-value < 0.05` == "Yes")
## [1] 26
sum(brain_structure_MDD_female$`Adjusted p-value < 0.05` == "Yes")
## [1] 29
sum(brain_structure_MDD_male$`Adjusted p-value < 0.05` == "Yes")
## [1] 2
Number of significant hits - balanced vs unbalanced
cat("Unbalanced comorbidity:")
## Unbalanced comorbidity:
sum(res_comorbidity_brain_structure_female_save$p.adjust < 0.05)
## [1] 88
sum(res_comorbidity_brain_structure_male_save$p.adjust < 0.05)
## [1] 4
cat("Balanced comorbidity:")
## Balanced comorbidity:
sum(res_comorbidity_brain_structure_balanced_f$p.adjust < 0.05)
## [1] 22
sum(res_comorbidity_brain_structure_balanced_m$p.adjust < 0.05)
## [1] 2
cat("Unbalanced CP:")
## Unbalanced CP:
sum(brain_structure_CP_female$`Adjusted p-value < 0.05` == "Yes")
## [1] 38
sum(brain_structure_CP_male$`Adjusted p-value < 0.05` == "Yes")
## [1] 14
cat("Balanced CP:")
## Balanced CP:
sum(res_CP_MDD_brain_structure_balanced_CP_f$p.adjust < 0.05)
## [1] 61
sum(res_CP_MDD_brain_structure_balanced_CP_m$p.adjust < 0.05)
## [1] 27
cat("Unbalanced MDD:")
## Unbalanced MDD:
sum(brain_structure_MDD_female$`Adjusted p-value < 0.05` == "Yes")
## [1] 29
sum(brain_structure_MDD_male$`Adjusted p-value < 0.05` == "Yes")
## [1] 2
cat("Balanced MDD:")
## Balanced MDD:
sum(res_CP_MDD_brain_structure_balanced_MDD_f$p.adjust < 0.05)
## [1] 43
sum(res_CP_MDD_brain_structure_balanced_MDD_m$p.adjust < 0.05)
## [1] 3